Prognostic Relevance of hMLH1, hMSH2, and BAX Protein Expression in Endometrial Carcinoma
نویسندگان
چکیده
منابع مشابه
Microsatellite instability and hMLH1 and hMSH2 expression in renal tumors.
Defects in the function of mismatch repair (MMR) genes result in genetic instability, a common feature of malignant progression. This study was conducted to determine the frequency of genetic instability [defined as microsatellite instability (MSI)] and to evaluate the sensitivity/specificity of immunohistochemistry in predicting the deficiency in MMR genes in renal cortical tumors. A total of ...
متن کاملDeficiency of hMLH1 and hMSH2 expression is a poor prognostic factor in Early Gastric Cancer (EGC)
Purpose: The aim of the study was to investigate the effect of deficiency of hMLH1 and hMSH2 expression on the prognosis of early gastric cancer (EGC) in Chinese populations. Methods: A total of 160 EGC patients who underwent curative gastrectomy with lymphadenectomy from January 2011 to July 2014 at Xinhua Hospital were evaluated. The expression rates of hMLH1 and hMSH2 were examined using tis...
متن کاملMethylation of hMLH1 in a population-based series of endometrial carcinomas.
Microsatellite instability (MSI) is a characteristic feature of hereditary nonpolyposis colorectal cancer and is also observed in sporadic colorectal and endometrial cancers. Alterations in the mismatch repair genes hMLH1 and hMSH2 are important for the development of MSI. It has recently been demonstrated that hypermethylation of the hMLH1 promoter region is associated with MSI and appears to ...
متن کاملDefective hMSH2/hMLH1 protein expression is seen infrequently in ulcerative colitis associated colorectal cancers.
BACKGROUND Ulcerative colitis is associated with an increased risk of colorectal cancer above that of the normal population. The relative risk correlates with the extent and duration of the disease but the genetic basis of ulcerative colitis associated cancer risk is not known. AIMS To assess the prevalence of microsatellite instability and mismatch repair gene abnormalities in ulcerative col...
متن کاملEstrogen up-regulates mismatch repair activity in normal and malignant endometrial glandular cells.
Impaired mismatch repair (MMR) is reportedly crucial in the early stages of endometrial carcinogenesis. Although estrogen exposure is considered an important risk factor for endometrial carcinoma, the relationship between estrogen and MMR activity remains undetermined. The present study was undertaken to elucidate the effect of estrogen on MMR activity in normal and malignant endometrial cells....
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2001
ISSN: 0893-3952,1530-0285
DOI: 10.1038/modpathol.3880389